# Linda Crnic Institute Data Sciences Program This GitHub organization serves as a home for code, workflows, and analysis pipelines associated with publications from the **Linda Crnic Institute for Down Syndrome Data Sciences Program**. ## Purpose This organization hosts and curates component repositories that: - Support published manuscripts and preprints - Enable reproducibility of analyses and figures - Provide reusable code for downstream research - Facilitate transparent and open science practices Repositories are generally organized at the level of individual studies, datasets, or analytical components, and may include code for: - RNA-seq and multi-omics analysis - Statistical modeling and visualization - Data processing and harmonization - Reproducible research workflows ## Scope The repositories in this organization represent work from the Data Sciences Program at the Crnic Institute and are closely tied to: - The **Human Trisome Project (HTP)** - Collaborative efforts within the **INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative** ## Related Resources - **Linda Crnic Institute for Down Syndrome** https://medschool.cuanschutz.edu/linda-crnic-institute - **Human Trisome Project (HTP)** https://www.trisome.org/ - **INCLUDE Data Coordinating Center (DCC)** https://includedcc.org/ - **INCLUDE Experimental Models of Down Syndrome portal** https://experimentalmodels.includedcc.org/ ## Reproducibility and Use Where possible, repositories include: - Documentation sufficient to reproduce primary analyses - Versioned code corresponding to specific publications - Links to public data repositories (e.g., GEO, Synapse, dbGaP) Users should consult individual repositories for: - Data access requirements - Software dependencies - Licensing and reuse terms ## Contact For questions about specific repositories or collaborations, please refer to the associated publication or repository maintainers. --- _This organization is maintained as part of ongoing efforts to support open, reproducible, and collaborative research in Down syndrome and related biomedical studies._